TY - JOUR T1 - Surfactant replacement therapy with a minimally invasive technique: Experience in a tertiary hospital JO - Anales de Pediatría (English Edition) T2 - AU - Canals Candela,F.J. AU - Vizcaíno Díaz,C. AU - Ferrández Berenguer,M.J. AU - Serrano Robles,M.I. AU - Vázquez Gomis,C. AU - Quiles Durá,J.L. SN - 23412879 M3 - 10.1016/j.anpede.2015.10.012 DO - 10.1016/j.anpede.2015.10.012 UR - https://www.analesdepediatria.org/en-surfactant-replacement-therapy-with-minimally-articulo-S2341287915002112 AB - IntroductionThe minimally invasive technique known as MIST (Minimally Invasive Surfactant Therapy), is a method which allows surfactant to be administered to a patient connected to non-invasive respiratory support. Use of this therapy is growing in Neonatal Units, as it reduces the intubation rate and the pathology associated with intubation and allows surfactant to be administered to patients in need. Patients and methodsIn 2013 and 2014 in the Hospital General Universitario de Elche surfactant was delivered using this method to 19 patients, 5 of whom had a gestational age of 28 or less weeks. Data were compared with a historical cohort consisting of 28 patients with Respiratory Distress Syndrome treated initially with non-invasive respiratory support. ResultsNo incidents were recorded that caused interruption of administration. A reduction in the fraction of inspired oxygen was observed in all cases after surfactant administration. Fewer intubations in the first 72h of life were found in the treatment group compared to the control group (42% vs. 54%). DiscussionThe experience in the Hospital General Universitario de Elche shows that administration of surfactant using the MIST technique is a reproducible method of treatment, which allows surfactant distribution during spontaneous breathing with non-invasive respiratory support. ER -