TY - JOUR T1 - Incidence and evolution of congenital heart disease in Spain from 2003 until 2012 JO - Anales de Pediatría (English Edition) T2 - AU - Pérez-Lescure Picarzo,Javier AU - Mosquera González,Margarita AU - Latasa Zamalloa,Pello AU - Crespo Marcos,David SN - 23412879 M3 - 10.1016/j.anpede.2017.12.008 DO - 10.1016/j.anpede.2017.12.008 UR - https://www.analesdepediatria.org/en-incidence-evolution-congenital-heart-disease-articulo-S2341287918301571 AB - Introduction and objectivesCongenital heart disease (CHD) represents the most common congenital malformation. The objective of this study was to analyse the incidence of CHD in Spain, and it is the first nationwide study so far. MethodsA retrospective observational study was performed in order to evaluate the incidence of CHD in Spain. The administrative database (minimum basic data set) from 2003 to 2012 was analysed in children less than one year old admitted to hospital with codes of CHD (International Classification of Diseases, 9th Revision, clinical modification). Cumulative incidence, incidence relative risk, and standardised incidence ratio were calculated to study geographic variations. ResultsThere were 64831 infants with CHD among the 4766325 births analysed during the period studied, with an incidence of 13.6‰. The incidence excluding atrial septal defect was 7.29 ‰. The most frequent CHD were atrial septal defect (6.31‰), ventricular septal defect (3.48‰), patent ductus arteriosus (2.71‰), coarctation of the aorta (0.55‰), pulmonary stenosis (0.50‰), transposition of the great arteries (0.49‰), atrioventricular septal defect (0.45‰), and tetralogy of Fallot (0.41‰).Castilla y León, together with Extremadura, showed the highest risks for severe and very severe CHD, while Madrid and Cantabria showed the lowest. ConclusionsAn increase of mild CHD was observed during the analysed period. This could have been influenced by improvements in diagnostic techniques, extended use of echocardiography, and the International Classification of Diseases, 9th Revision, clinical modification coding system, and a decrease in very severe CHD, which is less influenced by external factors. Significant geographical differences were found in the incidence of severe and very severe CHD. ER -