TY - JOUR T1 - Predictive markers of acute focal bacterial nephritis. A multicentre case-control study JO - Anales de Pediatría (English Edition) T2 - AU - Lucas García,Jesus AU - Oltra Benavent,Manuel AU - Ferrando Monleón,Susana AU - Marín Sierra,Juan AU - Rabasco Álvarez,María Dolores AU - Benito Julve,Pilar SN - 23412879 M3 - 10.1016/j.anpede.2020.01.007 DO - 10.1016/j.anpede.2020.01.007 UR - https://www.analesdepediatria.org/en-predictive-markers-acute-focal-bacterial-articulo-S2341287920301216 AB - IntroductionAcute focal bacterial nephritis is an interstitial bacterial infection, localised in the renal parenchyma, which can be more serious than acute pyelonephritis. The aim of this study is the analysis of predictive factors that may lead to its early diagnosis, which is essential for an adequate therapeutic approach. Patients and methodsA retrospective, multicentre case and control study. The participant centres were hospitals in Castellon and Valencia. The study period was 2010–2018, with the cases being patients with focal bacterial nephritis and the patients with pyelonephritis as controls. ResultsA total of 158 (1:1) patients were included. The median age of the cases was 2 years and there were 75% females. There were no differences in the clinical presentation. In the univariate analysis, focal nephritis was associated with malformations of the urinary tract, bacteraemia, the neutrophil count, and procalcitonin, as well as febrile convulsions of borderline significance. Procalcitonin values ≥2 ng/mL had an OR of 4.9 (95% CI; 1.77–13.85) of presenting with focal nephritis. In the multivariate analysis, the urological malformations still maintained statistical significance and borderline significance for procalcitonin. ConclusionsThe urinary tract malformations predispose the development of focal bacterial nephritis. In patients with a urinary tract infection and predictive factors of acute focal bacterial nephritis it would be worthwhile performing a renal Doppler ultrasound in the acute phase for its appropriate diagnosis and treatment. ER -