Systemic inflammatory response syndrome after cardiac operations

doi:10.1016/0003-4975(96)00055-0

The Annals of Thoracic Surgery

Volume 61, Issue 6, June 1996, Pages 1714-1720

https://doi.org/10.1016/0003-4975(96)00055-0 Get rights and content

Background

A systemic inflammatory response after open heart operation may be responsible for hyperdynamic circulatory instability and organ dysfunction. To what extent mediator release is involved needs to be clarified.

Methods

Ten patients with postoperative hyperdynamic circulatory dysregulation (group I) requiring application of α-constrictors and 10 patients with routine cardiac procedures and stable postoperative hemodynamic indices (group II) were analyzed for mediator release and metabolic and hemodynamic changes until the third postoperative day.

Results

Group I patients showed a significantly increased cardiac index and decreased systemic vascular resistance after bypass (cardiac index, group I: 5.2 ± 1.2 l · min⁻¹ · m⁻², group II: 2.5 ± 1.6 L · min⁻¹ · m⁻²; systemic vascular resistance, group I: 495 ± 204 dyne · s · cm⁻⁵, group II: 1,356 ± 466 dyne · s · cm⁻⁵) and at 3 hours (cardiac index, group I: 4.4 ± 0.8 L · min⁻¹ · m⁻², group II: 2.9 ± 0.6 L · min⁻¹ · m⁻²; systemic vascular resistance, group I: 567 ± 211 dyne · s · cm⁻⁵, group II: 1,053 ± 273 dyne · s · cm⁻⁵). Significantly higher serum levels of interleukin-6 were assessed in group I (postbypass, group I: 6,812 ± 9,293 pg/mL, group II: 295 ± 303 pg/mL; 3 hours, group I: 3,474 ± 5,594 pg/mL, group II: 286 ± 296 pg/mL). Concentrations of elastase, tumor necrosis factor, soluble tumor necrosis factor receptor, and interleukin-8 were elevated in group I (not significant). Early postoperative levels of soluble E-selectin and soluble intercellular adhesion molecule were also higher in group I (not significant). Continuously increased levels of endotoxin could be detected in only 3 of 10 patients in group I. Severe lactic acidosis (≥5 mmol/L) occurred in group I only.

Conclusions

Postoperative hyperdynamic instability after open heart operations appears to be associated with a certain pattern of mediator release. In particular, interleukin-6 appears to be involved in circulatory dysregulation and metabolic derangement.

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Original article: CardiovascularSystemic inflammatory response syndrome after cardiac operations

Background

Methods

Results

Conclusions

J Thorac Cardiovasc Surg

Ann Thorac Surg

Ann Thorac Surg

J Thorac Cardiovasc Surg

Ann Thorac Surg

J Thorac Cardiovasc Surg

J Thorac Cardiovasc Surg

Immunobiology

J Thorac Cardiovasc Surg

Cytokine

Original article: Cardiovascular
Systemic inflammatory response syndrome after cardiac operations