Elsevier

The Lancet

Volume 359, Issue 9311, 23 March 2002, Pages 1034-1036
The Lancet

Research Letters
Antibodies to varicella-zoster virus in blood donors with genetic variance in CC chemokine receptor 5

https://doi.org/10.1016/S0140-6736(02)08066-2Get rights and content

Summary

Carriers of a 32 bp deletion (Δ32) allele of the CC chemokine receptor 5 (CCR5) gene are reported to be more likely to lack antibodies to varicella-zoster virus than CCR5 wild-type individuals. To find out whether CCR5-Δ32 is associated with the seroprevalence of varicella-zoster virus infection, we tested blood donors with different CCR5-Δ32 genotypes for varicella-zoster virus lgG. Antibody to varicella-zoster virus was present in 209 (99·5%) of 210 CCR5-Δ32 carriers and exactly the same proportion of CCR5 wild-type individuals (209 of 210). We have therefore found no evidence that the CCR5-Δ32 allele is associated with decreased seroprevalence of varicella-zoster virus infection.

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