Elsevier

The Lancet

Volume 359, Issue 9316, 27 April 2002, Pages 1486-1488
The Lancet

Fast track — Research Letters
Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants

https://doi.org/10.1016/S0140-6736(02)08424-6Get rights and content

Summary

We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation. Echocardiography showed severely decreased pulmonary blood flow. Hypoxaemia resolved quickly on inhaled nitric oxide therapy. We suggest that investigators involved in similar trials pay close attention to pulmonary pressure if hypoxaemia occurs after prophylactic administration of ibuprofen.

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