Elsevier

The Lancet

Volume 364, Issue 9446, 6–12 November 2004, Pages 1699-1700
The Lancet

Research Letters
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

https://doi.org/10.1016/S0140-6736(04)17357-1Get rights and content

Summary

The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0·003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.

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