Journal of the American Academy of Dermatology
Case ReportPrimary cutaneous follicular center cell lymphoma of the nose with maxillary sinus involvement in a pediatric patient
Section snippets
Case report
In August 2000, a 16-year-old boy had an erythematous nodule on the left nasal ala and on the left naso-labial fold. Four years before, the cutaneous lesion had been diagnosed at another hospital as B-cell pseudolymphoma, with the histologic features of lymphoid hyperplasia. Molecular studies revealed polyclonality of immunoglobulin heavy chain (IgH) gene and T-cell receptor (TCR) gene, and cranial computed tomography (CT) was negative. The tumor had been surgically removed 4 times with
Discussion
In the pediatric age the most frequent lymphomas are Burkitt's lymphoma, lymphoblastic B-cell lymphoma, and CD30+ anaplastic large cell lymphoma,3, 4 which arise in extracutaneous sites and may secondarily involve the skin. Primary cutaneous lymphomas, except CD30+ disorders,5 mycosis fungoides,6 and panniculitis-like T-cell lymphoma,7 are rare in children and PCFCCL has never been described, to our knowledge.
PCFCCL has been reported as an indolent neoplasm of B-cell origin, which rarely
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Cited by (28)
Diagnosis and Management of Cutaneous B-Cell Lymphomas
2019, Dermatologic ClinicsCitation Excerpt :It is also male predominant and tends to occur in middle-aged and older patients, with a median age in the 50s.14–16 It rarely occurs in children, with only 3 previously reported pediatric cases.35–38 Patients with PCFCL present with either single or multiple papules, plaques, or tumors with pink to purple coloration and may display peripheral erythema; surrounding plaques and papular lesions may also be seen (Fig. 3).
Primary cutaneous B-cell lymphomas with large cell predominance–primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma
2017, Seminars in Diagnostic PathologyCitation Excerpt :Primary cutaneous follicle center lymphoma accounts for approximately 50–60% of primary cutaneous B-cell lymphomas5,7,8 and occurs in middle aged-to older men and women, with a cited median age generally in the 50 s,7–9,11 and a slight male predominance in some studies.8 The disease is extremely rare in children, with only three cases reported in the literature;32–35 however, it can be seen in young adults.36 Patients usually present with erythematous papules, plaques or tumors most commonly on the head, neck or trunk (Fig. 1), although any site can be involved, including the leg.
Cutaneous infiltrates - lymphomatous and leukemic
2009, Weedon's Skin Pathology: Third EditionSubcutaneous nodules as a sign of malignant lymphoproliferative syndrome
2009, Anales de PediatriaAdolescent with primary cutaneous follicle center lymphoma treated with rituximab
2024, Pediatric Blood and CancerAn adolescent with primary cutaneous follicle center lymphoma: a case report and literature review
2023, Frontiers in Oncology
This supplement is made possible through the generous support of Stiefel Laboratories for the American Academy of Dermatology.
Funding sources: None.
Conflicts of interest: None identified.
The case has been presented at the 1st National Congress of Dermatology and Venereology ADOI-SIDEV June 2001, Rome, Italy.