Asthma and lower airway diseaseThe Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis
Section snippets
Search strategy and selection criteria
Electronic databases, including PubMed (1998 to December 2011), CENTRAL (Cochrane Controlled Trials Register, issue 1, 2012), Web of Science (1998 to December 2011), Ovid (1998 to December 2011), and Embase (1998 to December 2011), were searched for relevant articles. Details are provided in the Methods section in this article’s Online Repository at www.jacionline.org.
Data extraction
The following details were extracted from each included article: authors, year of publication, study population, settings, race
Included studies
Our search strategy initially yielded 1607 citations (Fig 1). Of these, 21 eligible trials that used the ACT (n = 12), the ACQ (n = 6), or both (n = 3) to assess asthma control were included in our study.4, 6, 7, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 One was a poster abstract, and 2 were real-world studies.
Study characteristics and quality of reporting
Table II and Tables E2 to E5 and Fig E1 (available in this article’s Online Repository at www.jacionline.org) show the characteristics and quality of
Discussion
To our knowledge, this is the first study to systematically explore the diagnostic performances of the ACT and ACQ in assessments of levels of asthma control and to provide comparative analyses. Our study suggests that the ACT provided a good diagnostic accuracy for assessments of controlled and not well-controlled asthma and that the ACQ (ACQ-7 and ACQ-6) accurately assessed not well-controlled asthma at prespecified cutoff points. However, the sensitivity and specificity of the ACQ were in a
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Supported by the National Natural Science Foundation of China (30971326 and 30901907), the Sichuan Youth Science and Technology Foundation (2010JQ0008), and Youth Science Funding of Sichuan University (2011SCU04B17).
Disclosure of potential conflict of interest: G. Wang has received grants from the National Natural Science Foundation of China, the Sichuan Youth Science and Technology Foundation, Youth Science Funding of Sichuan University; and has received an APSR Research/Training Fellowship (2011) and a scholarship as visiting Associated Professor at the University of Newcastle, Australia. The rest of the authors declare that they have no relevant conflicts of interest.
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These authors contributed equally to this work.