Food, drug, insect sting allergy, and anaphylaxisIncreased food diversity in the first year of life is inversely associated with allergic diseases
Section snippets
Study design and population
The PASTURE/EFRAIM study is a prospective birth cohort involving children from rural areas in 5 European countries (Austria, Finland, France, Germany, and Switzerland) designed to evaluate risk factors and preventive factors for atopic diseases.15 Pregnant women were recruited during the third trimester of pregnancy between August 2002 and March 2005 and divided into 2 groups. Women who lived on family-run farms where any kind of livestock was kept were assigned to the farm group. Women from
Characteristics and prevalence of allergic diseases
Among the 856 children included in this study, 51.5% were farmer children, and 53.6% had at least 1 allergic parent (Table I). The description of food diversity was mentioned in our previous study.14 Farmer children received a higher number of different food items in the first year of life compared with nonfarmer children. Differences between centers were observed regarding the diversity score, with a higher proportion of French and German children having a low score. A higher proportion of
Discussion
Our data show that an increased diversity of food introduced in children's diet within the first year of life is negatively associated with the development of asthma and food allergy up to 6 years of age and on sensitization to food allergens at 4.5 or 6 years of age. Moreover, among children with a low food diversity score, we found an increased expression of marker for antibody isotype switching to IgE and a reduced expression of the regulatory T cell–associated gene Foxp3 measured at 6 years
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Supported by European Union research grants PASTURE/EFRAIM (QRLT4-CT 2001-00250, KBBE-2-2-06) and the Kühne Foundation.
Disclosure of potential conflict of interest: M. Depner has received one or more grants from or has one or more grants pending with the European Research Council. B. Schaub has received one or more grants from or has one or more grants pending with DFG, European Union. J. Genuneit has been supported by one or more grants from the European Union. J.-C. Dalphin has received one or more consulting fees or honoraria from and has received support for travel from Chiesi; has consultancy arrangements with Novartis and Intermune; has received one or more grants from or has one or more grants pending with Novartis; has received one or more payments for lecturing from or is on the speakers' bureau for Novartis, GlaxoSmithKline, AstraZeneca, and Chiesi; has received one or more payments for the development of educational presentations for Novartis, Chiesi, GlaxoSmithKline, AstraZeneca, Intermune, and Boehringer Ingelheim; and has received one or more payments for travel/accommodations/meeting expenses from Novartis, Chiesi, and GlaxoSmithKline. E. von Mutius has been supported by one or more grants from the European Commission; is a Board member for the American Academy of Allergy, Asthma & Immunology; has consultancy arrangements with GlaxoSmithKline, Novartis, Protectimmun, ALK-Abelló, and Astellas Pharma Europe; has provided expert testimony for the UK Research Excellence Framework; and has received one or more payments for lecturing from or is on the speakers' bureau for InfectoPharm and for Nestlé Research. R. Lauener has been supported by a European Union Research Grant and a Kühne Foundation Research Grant; has received support for travel from the European Union and from the Kühne Foundation; has consultancy arrangements with the National Advisory Boards of ALK-Abelló, Nestlé, Novartis, MSD, MEDA, Allergopharma, and Menarini; has received one or more grants from or has one or more grants pending with Study Nestec; and has received one or more payments for lecturing from or is on the speakers' bureau for ALK-Abelló and for Nestlé. The rest of the authors declare that they have no relevant conflicts of interest.
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The members of the PASTURE study group are (in alphabetical order by study center): Maija-Riitta Hirvonen, Sami Remes, Marjut Roponen, and Pekka Tiittanen (Finland); Marie-Laure Dalphin and Vincent Kaulek (France); Gisela Büchele, Markus Ege, Michael Kabesch, and Harald Renz (Germany); and Gert Doekes (The Netherlands).