Current therapyInfantile Cortical Hyperostosis (Caffey Disease): A Review
Section snippets
Case Report
Our patient was born October 1999 (weight, 3.31 kg; size, 49 cm; cephalic perimeter, 36 cm). Parents were nonrelated. The mother experienced 6 miscarriages, giving birth to a healthy boy in 1996. Another miscarriage occurred before our patient was born. At birth, an angulation of both legs was seen. X-rays showed important hyperostosis of the tibia and the distal part of both humerus. The cranial vault appears normal, but the mandible presents hyperostosis (Fig 1). Pain was present for 5 months
First Description
Infantile hyperostosis was described initially by Caffey and Silverman in 1945.5 They described a group of infants with tender swelling in the soft tissues and cortical thickenings in the skeleton, with onset of these findings during the first 3 months of life.
Epidemiology
It has been reported that infantile hyperostosis affects 3 in every 1,000 infants less than 6 months of age in the United States, with no predilection by ethnic origin or gender.6 Both familial and sporadic forms occur. The familial form
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2024, DifferentiationProbable micronutrient deficiency diseases in a rural community. The nonadults of Mary's Nativity church, 16th century, Trentino Alto-Adige, Italy
2023, Journal of Archaeological Science: ReportsCitation Excerpt :Childhood Cortical Hyperostosis (ICH) led to the cortical hyperostosis of ribs, pelvis and long bones; the latter also show bending of the diaphysis, a characteristic also found in our sample. However, in no case we noted marked expression of hyperostosis that instead characterizes ICH (Rusu et al., 2019; Spranger et al., 2018; Kamoun-Goldrat and Le Merrer, 2008), and this allows us to exclude it. Infantile tibia vara (Blount's disease) led to the tibial bowing and a medial depression of the proximal tibia (Janoyer, 2019; Lagiere et al., 1991); the absence of these features allowed us to exclude this diagnosis.
A probable case of infantile cortical hyperostosis in 2nd–4th centuries AD Romania
2019, International Journal of PaleopathologyCitation Excerpt :The outcome of the disease is influenced by whether the condition is inherited or sporadic, and the age of onset. The inherited form has a slightly earlier onset, with 24% of cases displaying the disease at birth, while the sporadic form is not usually manifested before 9 weeks (Kamoun-Goldrat and le Merrer, 2008). Prenatal cortical hyperostosis, also known as Caffey’s Dysplasia, is usually more severe, particularly when the age of onset is before 35 weeks in utero, in which case the fetus usually does not survive (Nemec et al., 2012).
Hypertrophic Osteoarthropathy in an adult Macaque
2019, International Journal of PaleopathologyCitation Excerpt :HOA may be classified as either primary or secondary, with the former only accounting for approximately 5% of clinical cases (Yap et al., 2016). Very little is known about primary HOA, although it has been suggested that a genetically controlled growth promoting factor is involved (Martínez-Lavín et al., 1988; Kelle et al., 2017). Although the pathogenesis of HOA is not fully understood, secondary HOA typically occurs secondary to pulmonary, cardiac, intestinal or hepatic diseases, and most commonly is considered a paraneoplastic syndrome that occurs secondary to pulmonary and plural tumors (Lawler et al., 2015).