PathologyLabial Salivary Gland Biopsy in the Investigation of Neonatal Hemochromatosis
Section snippets
Report of a Case
A premature female infant was delivered by cesarean section at a community hospital to a 29-year-old gravid 4, para 2, term 2 with 1 abortion after a pregnancy of 35 weeks complicated by pre-eclampsia. The child's birth weight was 2,530 g and the Apgar scores were 2/8. Shortly after birth, the baby was cyanotic and inactive and required ventilatory support. In the neonatal intensive care unit, blood was noted to be oozing from the umbilicus. The following hematologic abnormalities were
Discussion
Neonatal hepatic failure has a range of possible etiologies such as infectious, metabolic, idiopathic, drug related, and NH. NH is a heterogenous disorder from a clinical and an etiologic perspective. A range of clinical severity has been described in infants with NH, but it is commonly regarded as a grave hepatic injury and often associated with a poor prognosis. The serious effects of NH result from iron accumulation involving the liver, but iron accumulates in other tissues, such as minor
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