Original ArticleCreatine kinase MB (CK-MB) in benign paroxysmal vertigo of childhood: A new diagnostic marker
Section snippets
Methods
From December 1998 to March 2003, 22 children were diagnosed with BPV at the Department of Pediatrics, Falun Hospital. All children were referred to and followed up by one of the authors. The Department of Pediatrics serves 67,000 children up to the age of 18 years.
The diagnosis was based on preset criteria. In many cases, electroencephalography, CT of the brain, and MRI were performed to exclude other conditions. The criteria were (1) recurrent episodes of vertigo and a sensation of spinning
Results
Of the 22 children who were diagnosed with BPV from December 1998 to March 2003, 15 (68.2%) were girls and 7 (31.8%) were boys. Average age when BPV was diagnosed was 2.1 (SD, 0.8) years, and history of debut age was 1.7 years (SD, 0.9). No child had an onset after 4 years of age. Average follow-up time was 2.8 years (SD, 1.4; range, 12 months to 5 years). The number of episodes per month at peak was 1 in 4 children, 2 in 5 children, 3 to 19 in 6 children, and more than 24 episodes per month in
Discussion
There are no known markers in serum for the diagnosis of BPV. The elevation of CK-MB levels in children with BPV was first discovered by chance in the first patient in this series. This finding led to the current study. Our results show that CK-MB was increased during BPV and in a large proportion of patients at each observation. In no case was CK-MB normal at the first two observations after diagnosis of BPV. A prospective, population-based study would be required to determine sensitivity and
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Cited by (16)
Clinical characteristics of vestibular evoked myogenic potentials in children with recurrent vertigo of childhood
2022, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :It is generally believed that some aspects of children's vestibular function are very mature and others will continue to mature until adolescence [16]. Dan et al. [17] found that creatine kinase MB (CK-MB) in children with RVC increased during the onset of the disease. After excluding the increase of CK-MB caused by heart disease, it was recommended as an indicator for the diagnosis of RVC.
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Supported by the Center for Clinical Research, Falun, Sweden.