Original ArticleClinical Responses of Patients with Kawasaki Disease to Different Brands of Intravenous Immunoglobulin
Section snippets
Case Collection
This study was approved by Institutional Review Board of Chang Gung Memorial Hospital. We retrospectively reviewed the charts of all the children who were diagnosed as having KD and who were treated with IVIG at Chang Gung Children's Hospital from February 1994 to July 2003. KD was defined as an acute febrile illness with fever for at least 5 days plus at least 4 of the following criteria: bilateral nonpurulent bulbar conjunctivitis, red lips with fissure or strawberry tongue, indurative edema
Demography and Clinical Profiles
A total of 437 cases of KD in 435 patients were collected in this study as users of 1 of 4 brands of IVIG: Brand A 91 cases, Brand B 182, Brand C 93, and Brand D 71. Two patients had recurrent KD: one recurred 2 months after the first episode and the other recurred 3 months after the first episode. Two hundred seventy-six (63%) of patients with KD were male, and the mean age was 18.7 months (range 1-108 months, median age 13 months) at the time of diagnosis. Table II presents the data on the 4
Discussion
Our study suggests that the different preparations of IVIG may result in different clinical outcomes of children with KD. In this study patients receiving Brand C IVIG had a significantly higher rate of CAA at convalescence and a significantly higher rate of IVIG nonresponsiveness compared with those receiving the other 3 IVIG brands. Three patients had development of giant aneurysms, 2 of whom had a myocardial infarction. Our multivariate analysis found being treated with Brand C IVIG to be
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