Original articleBisphosphonate Treatment in Chronic Recurrent Multifocal Osteomyelitis
Section snippets
Case Histories
Clinical details and pamidronate dosing for each patient are summarized in Table I. Radiological changes are summarized in Table II.
Discussion
In this case series of pamidronate use in CRMO, objective evidence of reduction in lesion size has been demonstrated. One earlier case series of children with the related SAPHO syndrome has shown symptomatic improvement only, with no objective change in lesion size.16 Earlier case reports of CRMO have shown response to treatment in individual patients. Four of our 5 patients showed clinical response, with some radiographic changes in all 4 patients. The fifth patient may have had some minimal
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