Original ArticleMultimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke
Section snippets
Methods
The objective of the AVCnn study was to better delineate the risk factors, clinical and imaging presentation, mechanisms, and outcomes of NAIS, while avoiding the confounders described above. The study was conducted in accordance with international ethical standards and the Declaration of Helsinki. The current evaluation at age 7 years was approved by the Regional Ethics Committee in May 2010. Informed consent was obtained from each participant. The reporting of results follows the general
Results
Of the 100 patients (Figure 1; available at www.jpeds.com), 2 died in the neonatal period, and 13 families were lost to follow-up. Of the 85 families contacted for the 7-year assessment, 5 declined to participate and 73 accepted. Seven other families refused to participate in the encounter but agreed to complete part of the evaluation by phone. In these families, data on epilepsy, schooling, and parental opinions were recorded.
Data were available for 80 families (82% of the survivors). The
Discussion
In this cohort of term newborns with NAIS, most children exhibited some sequelae 7 years later; however, severe disability, such as drug-resistant epilepsy, moderate/severe CP (GMFCS ≥III or BFMF ≥3), or global intellectual deficiency, is the exception: 6%, 3%, and 8%, respectively, with a major co-occurrence. In other words–and to answer to a common question of parents–all were able to walk independently and to talk. These results are in line with previously reported data, but our study has
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Funded by Ministère de la santé et des solidarités (0308052 and 1008026), Centre hospitalier universitaire de Saint-Étienne (085), Fondation motrice, Fondation Garches, Association des paralysés de France, and Fondation de France. The authors declare no conflicts of interest.
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List of additional AVCnn Study Group members is available in the Appendix (available at www.jpeds.com).