Lung transplantationPediatric Lung Transplantation
Section snippets
Patients and methods
From October 1993 to December 2003, 165 patients underwent LT, including 23 children younger than 16 years (study group). The indications for LT in the pediatric population were cystic fibrosis in 21 patients, pulmonary fibrosis in 1, and Kartagener syndrome in 1. The donor selection criteria followed those generally accepted for adult patients (age younger than 55 years, normal chest x-ray film, oxygenation index (arterial oxygen tension/forced inspiratory oxygen [Pao2/Fio2]) greater than 300
Results
Twenty-three children younger than 16 years received LTs during the study period, including 10 boys and 13 girls, with mean age 11.9 ± 2.9 years (range, 5–16), compared with 142 concurrent adult LT patients. The actuarial survival rates of pediatric versus adult LT patients were not significantly different; 8-year survival rate was 62% in children, versus 41% in adults (Fig 1). In children the causes of post-LT death were cardiac failure in 4 cases, bronchiolitis in 2, non-cytomegalovirus
Discussion
From the inception of our Lung Transplant Program in October 1993, to September 2003, we have transplanted lungs in 165 patients, with excellent results. The outcomes of our initial experience with LT have been reported previously.7 Since then, 23 children have received transplants. Pediatric LT recipients as a whole are probably at higher risk, based on their pretransplantation clinical status and diagnosis. In our experience, children undergoing LT more frequently required cardiopulmonary
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Cited by (17)
Lung transplantation in children: Challenges and realities
2011, Anales de PediatriaLung transplantation for cystic fibrosis: Current concepts and one center's experience
2007, Journal of Cystic FibrosisCitation Excerpt :With some exceptions, complications in the pediatric population are similar to those in adults. Pediatric lung transplant recipients appear to have a higher incidence of pneumonia and acute rejection in the early post-operative period when compared to their adult counterparts [121] and so antibiotics targeting organisms cultured pre-transplant are important in the peri-operative period. Acute rejection, however, seems to be less prevalent in infants.
Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure
2006, Journal of PediatricsCitation Excerpt :The families of the children with developmental disorders do feel that their children have an acceptable quality of life. Pulmonary function studies were normal, suggesting normal lung growth, unless the course was complicated by bronchiolitis obliterans, the major factor limiting survival for all patients undergoing lung transplantation.12,16-19 Two of the three SP-B–deficient infants who survived more than 5 years had bronchiolitis obliterans, a frequency that was similar to the other two groups.
Transplants: Lung transplantation
2006, Anales de Pediatria ContinuadaLung transplantation in adolescents
2019, Pediatric MedicineKartagener syndrome: A case report
2018, Asian Journal of Pharmaceutical and Clinical Research