Pediatric Case ReportLabial Ecthyma Gangrenosum in an Immunocompromised Infant With Leukemia: Heightening Awareness for the Urologist
Section snippets
Case Report
An 11-month-old girl with high-risk infant B-precursor acute lymphoblastic leukemia (ALL) in the consolidation phase of chemotherapy was admitted to the Children's Hospital of Philadelphia with fever and chemotherapy-associated neutropenia. She had been severely neutropenic, with an absolute neutrophil count (ANC) of <200 cells/μL, for at least 7 days before admission. Her parents had also noted mild right labial erythema, swelling, and discomfort with diaper changes for 3 days before
Comment
EG is a rare cutaneous lesion classically associated with P. aeruginosa sepsis that occurs most frequently in severely immunocompromised patients.1, 2, 3 It is characterized by erythematous, hemorrhagic, or necrotic macules or plaques, most commonly of the perineal or gluteal skin, that can rapidly progress into a gangrenous ulcer or eschar.1 Although most commonly caused by P. aeruginosa, EG has also been associated with other bacteria, including Aeromonas hydrophila, Staphylococcus aureus,
References (10)
- et al.
Perineal ecthyma gangrenosum in infancy and early childhood: septicemic and nonsepticemic forms
J Am Acad Dermatol
(1992) - et al.
Ecthyma gangrenosum: report of clinical, histopathologic, and bacteriologic aspects of eight cases
J Am Acad Dermatol
(1984) - et al.
Nonpseudomonal ecthyma gangrenosum
J Am Acad Dermatol
(2004) - et al.
Necrotic skin lesions associated with disseminated candidiasis
Arch Dermatol
(1979) Cutaneous and soft-tissue manifestations of sepsis due to gram-negative enteric bacilli
Rev Infect Dis
(1980)
Cited by (7)
Ecthyma gangrenosum as an initial manifestation of acute lymphoblastic leukemia
2022, Anales de PediatriaEcthyma gangrenosum as a serious complication of Pseudomonas aeruginosa infection in departments of paediatric oncology
2021, Postepy Dermatologii i AlergologiiEcthyma gangrenosum in a 3-year-old boy post-heart transplantation
2019, Transplant Infectious DiseaseA case of perineal ecthyma gangrenosum
2016, Turk Pediatri ArsiviA healthy infant with an ulcerated genital lesion: Diagnostic and therapeutic considerations
2016, Pediatric Emergency CareEcthyma gangrenosum and ecthyma-like lesions: review article
2015, European Journal of Clinical Microbiology and Infectious Diseases
Gregory E. Tasian and Sarah K. Tasian contributed equally to this work.
Financial Disclosure: The authors declare that they have no relevant financial interests.
Funding Support: Dr. Gregory Tasian is supported by National Institutes of Health (NIH)-5T32HD060550-03. Dr. Sarah Tasian is supported by NIH-K12CA076931.