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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La artritis idiop&#225;tica juvenil es una enfermedad inflamatoria cr&#243;nica que precisa con frecuencia corticoterapia&#46; El retraso del crecimiento puede ser un problema importante en estos pacientes&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudiar el crecimiento de los ni&#241;os con artritis idiop&#225;tica juvenil y analizar los factores implicados en las alteraciones de &#233;ste&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 91 pacientes con artritis idiop&#225;tica juvenil&#44; seguidos durante al menos un a&#241;o&#46; Se realiz&#243; un estudio de corte transversal&#44; uno longitudinal retrospectivo y otro prospectivo&#46; Se valor&#243; la talla en la primera consulta&#44; en el estudio transversal y un a&#241;o antes&#46; Se calcul&#243; la velocidad de crecimiento&#46; Se estudiaron par&#225;metros relacionados con la actividad de la enfermedad&#44; con la corticoterapia&#44; con el estado nutritivo&#44; con la situaci&#243;n hormonal y la densidad mineral &#243;sea &#40;DMO&#41;&#46; Se realiz&#243; un estudio de correlaci&#243;n y un an&#225;lisis de regresi&#243;n multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La talla fue inferior o igual a &#8211;2 desviaciones est&#225;ndar &#40;DE&#41; en el 14&#44;3&#37; del total de los pacientes y en el 55&#44;6&#37; de las formas sist&#233;micas&#46; Los factores asociados de forma independiente con la talla fueron la dosis total de corticoids recibida&#44; la clase funcional&#44; el &#237;ndice nutricional&#44; la DMO y la edad de comienzo de la enfermedad&#46; La velocidad de crecimiento fue inferior a lo normal en el 25&#44;3&#37; del total y en el 61 &#37; del grupo sist&#233;mico y los factores asociados de forma independiente con ella fueron la dosis de corticoide y el n&#250;mero de articulaciones inflamadas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El retraso en el crecimiento en pacientes con arthritis idiop&#225;tica juvenil se asoci&#243; a factores relacionados con la enfermedad&#44; con la corticoterapia&#44; con el estado nutritivo&#44; con la DMO y con el comienzo precoz de la enfermedad&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Juvenile idiopathic arthritis &#40;JIA&#41; is a chronic inflammatory disease that often requires steroid therapy&#46; Growth retardation can be a serious complication in some of these patients&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To study linear growth in patients with JIA and evaluate the factors involved in its disturbance&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We studied 91 patients with JIA with a follow-up of at least one year&#46; A cross sectional study&#44; a longitudinal retrospective study&#44; and a longitudinal prospective study were performed&#46; Height in the first consultation&#44; in the cross sectional study&#44; and one year previously was evaluated&#46; Height velocity &#40;HV&#41; was calculated&#46; Several parameters related to disease activity&#44; corticosteroid therapy&#44; nutritional and hormonal status&#44; and bone mineral density &#40;BMD&#41; were analyzed&#46; A correlation study and multivariate regression analysis were carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Height was &#35; &#8804;2 SD in 14&#46;3 &#37; of the series and in 55&#46;6&#37; of the systemic group&#46; Variables independently associated with height were total corticosteroid dose&#44; functional class&#44; nutritional index&#44; BMD&#44; and age at onset of the disease&#46; HV was &#35; &#8804;2 SD in 25&#46;3 &#37; of the series and in 61 &#37; of the systemic group&#46; Variables independently associated with HV were corticosteroid dose and the number of swollen joints&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Growth retardation in patients with JIA was associated with factors related to the disease&#44; corticosteroid therapy&#44; nutritional status&#44; BMD&#44; and earlier onset of the disease&#46;</p>"
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Vol. 58. Issue 6.
Pages 529-537 (1 June 2003)
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Vol. 58. Issue 6.
Pages 529-537 (1 June 2003)
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Crecimiento en niños con artritis idiopática juvenil
Growth in children with juvenile idiopathic arthritis
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12355
J. García-Consuegra Molinaa,
Corresponding author
reumaped.hulp@salud.madrid.org

Correspondencia: Unidad de Reumatología Pediátrica. Hospital Infantil La Paz. P.° de la Castellana, 261. 28046 Madrid. España.
, R. Merino Muñoza, R. Lama Moreb, J. Coya Viñac, R. Gracia Bouthelierd
a Unidades de aReumatología Pediátric. Hospital Universitario Infantil La Paz. Madrid. España.
b Nutrición Pediátrica. Hospital Universitario Infantil La Paz. Madrid. España.
c Servicios de Medicina Nuclear. Hospital Universitario Infantil La Paz. Madrid. España.
d Endocrinología Pediátrica. Hospital Universitario Infantil La Paz. Madrid. España.
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Introducción

La artritis idiopática juvenil es una enfermedad inflamatoria crónica que precisa con frecuencia corticoterapia. El retraso del crecimiento puede ser un problema importante en estos pacientes.

Objetivo

Estudiar el crecimiento de los niños con artritis idiopática juvenil y analizar los factores implicados en las alteraciones de éste.

Métodos

Se estudiaron 91 pacientes con artritis idiopática juvenil, seguidos durante al menos un año. Se realizó un estudio de corte transversal, uno longitudinal retrospectivo y otro prospectivo. Se valoró la talla en la primera consulta, en el estudio transversal y un año antes. Se calculó la velocidad de crecimiento. Se estudiaron parámetros relacionados con la actividad de la enfermedad, con la corticoterapia, con el estado nutritivo, con la situación hormonal y la densidad mineral ósea (DMO). Se realizó un estudio de correlación y un análisis de regresión multivariante.

Resultados

La talla fue inferior o igual a –2 desviaciones estándar (DE) en el 14,3% del total de los pacientes y en el 55,6% de las formas sistémicas. Los factores asociados de forma independiente con la talla fueron la dosis total de corticoids recibida, la clase funcional, el índice nutricional, la DMO y la edad de comienzo de la enfermedad. La velocidad de crecimiento fue inferior a lo normal en el 25,3% del total y en el 61 % del grupo sistémico y los factores asociados de forma independiente con ella fueron la dosis de corticoide y el número de articulaciones inflamadas.

Conclusiones

El retraso en el crecimiento en pacientes con arthritis idiopática juvenil se asoció a factores relacionados con la enfermedad, con la corticoterapia, con el estado nutritivo, con la DMO y con el comienzo precoz de la enfermedad.

Palabras clave:
Artritis idiopática juvenil
Crecimiento
Nutrición
Osteoporosis
growth in children with juvenile idiopathic arthritis
Introduction

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that often requires steroid therapy. Growth retardation can be a serious complication in some of these patients.

Objective

To study linear growth in patients with JIA and evaluate the factors involved in its disturbance.

Methods

We studied 91 patients with JIA with a follow-up of at least one year. A cross sectional study, a longitudinal retrospective study, and a longitudinal prospective study were performed. Height in the first consultation, in the cross sectional study, and one year previously was evaluated. Height velocity (HV) was calculated. Several parameters related to disease activity, corticosteroid therapy, nutritional and hormonal status, and bone mineral density (BMD) were analyzed. A correlation study and multivariate regression analysis were carried out.

Results

Height was # ≤2 SD in 14.3 % of the series and in 55.6% of the systemic group. Variables independently associated with height were total corticosteroid dose, functional class, nutritional index, BMD, and age at onset of the disease. HV was # ≤2 SD in 25.3 % of the series and in 61 % of the systemic group. Variables independently associated with HV were corticosteroid dose and the number of swollen joints.

Conclusions

Growth retardation in patients with JIA was associated with factors related to the disease, corticosteroid therapy, nutritional status, BMD, and earlier onset of the disease.

Key words:
Juvenile idiopathic arthritis
Growth
Nutrition
Osteoporosis
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