Casos de enfermedad de sintomatología neurológica asociados al consumo de anís estrellado empleado como carminativo
Cases of neurological symptoms associated with star anis consumption used as a carminative
C. Garzo Fernándeza,
, P. Gómez Pintadob, A. Barrasa Blancob, R. Martínez Arrietac, R. Ramírez Fernándezd, F. Ramón Rosac, por el Grupo de Trabajo del Anís Estrellado
Corresponding author
cgf02m@saludalia.com
Correspondencia: Servicio de Neurología Pediátrica. Hospital General Universitario Gregorio Marañón. Madrid. España.
Correspondencia: Servicio de Neurología Pediátrica. Hospital General Universitario Gregorio Marañón. Madrid. España.
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"etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Instituto Madrileño de Salud Pública." "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Neurología Pediátrica. Hospital General Universitario Gregorio Marañón. Madrid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cases of neurological symptoms associated with star anis consumption used as a carminative" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-06-30" "fechaAceptado" => "2002-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec187039" "palabras" => array:3 [ 0 => "Anís estrellado" 1 => "<span class="elsevierStyleItalic">Illicium verum Illicium anisatum</span> Convulsiones" 2 => "Intoxicación Epidemiología" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec187038" "palabras" => array:5 [ 0 => "Star anise" 1 => "<span class="elsevierStyleItalic">Illicium verum</span>" 2 => "Illicium anisatum Convulsions" 3 => "Poisoning" 4 => "Epidemiology" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Desde marzo de 2001 se observaron en España una serie de niños, menores de 3 meses, que presentaban sintomatologia digestiva y neurológica grave, presuntamente asociada al consumo de anís estrellado. Se inició un estudio epidemiológico con el objetivo de conocer las caracteristicas de los afectados y valorar la asociación entre el cuadro y el consumo de anís.</p> <span class="elsevierStyleSectionTitle">Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de casos-controles apareados (1:2), en niños menores de 3 meses ingresados en las urgencias pediátricas de dos hospitales de Madrid, entre febrero y septiembre de 2001. Se emplearon <span class="elsevierStyleItalic">odds ratio</span> (OR) de Mantel-Haenzel y regresión logística condicionada para cuantificar la asociación y la dosis-respuesta. Se realizaron análisis de laboratorio de las sustancias implicadas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 23 casos. La sintomatología consistió en irritabilidad (78,3%), movimientos anormales y vómitos (56,5 %), nistagmo (52,2 %) y episodios de desaturación de oxígeno (21,7%). En el estudio de casos-controles se emplearon 18 casos y 36 controles. Nueve (25%) controles consumieron anís estrellado (exposición leve, 5 casos; alta, 4 casos). La OR de Mantel-Haenzel fue de 18,0 (intervalo de confianza [IC] del 95%, 2,03–631) y para la dosis-respuesta de 11,7 (IC 95 %, 1,3–188,5) en la exposición leve y de 18,2 (IC 95%, 1,8–183,5) en la alta. Los análisis de laboratorio mostraron contaminación de <span class="elsevierStyleItalic">Illicium verum con Illicium anisatum</span>.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se confirma la relación entre la enfermedad y el consumo de anís estrellado. La asociación se refuerza en los análisis de dosis-respuesta. Se encontró contaminación del producto con otras especies de anís. Se recomienda destrucción de las partidas contaminadas, no utilizar en lactantes y divulgación de los resultados entre pediatras.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Since March 2000, a series of infants with serious gastrointestinal and neurological symptoms have been observed in Spain. These symptoms were suspected to be associated with the use of star anise infusion. We performed an epidemiological study to determine the characteristics of these patients and to evaluate the association between the symptoms and anise consumption.</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">From February to September 2001, a matched case-control study (1:2) was performed among infants aged less than 3 months admitted to the pediatric emergency departments of two hospitals in Madrid. Mantel-Haenszel and conditional logistic regression odds ratios (OR) were calculated to quantify the association and the dose-response relationship. Laboratory analyses of the implicated substances were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Twenty-three cases were studied. The mean age was 29.2 days (SD: 25.5). The symptoms observed were irritability, abnormal movements, vomiting and nystagmus. Eighteen cases and 36 controls were included in the case-control study. Nine controls (25 %) consumed anis infusion (consumption was high in five and low in four). The Mantel-Haenszel OR was 18.0 (2.03–631) and the OR for the dose-response relationship was 11.7 (95 % CI: 1.3–188.5) for low levels of consumption and 18.2 (95% CI: 1.8–183.5) for high levels. Laboratory analyses revealed contamination of <span class="elsevierStyleItalic">Illicium verum by Illicium anisatum</span></p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">This study confirms the association between the symptoms described and the use of anise infusion. The dose response analyses provide further evidence for the association. Cross-contamination was found between the product and other anise species. We recommend destruction of the contaminated products, avoidance of anise infusions among infants, and dissemination of the results among pediatricians.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 24 | 17 | 41 |
| 2024 September | 64 | 55 | 119 |
| 2024 August | 78 | 92 | 170 |
| 2024 July | 56 | 60 | 116 |
| 2024 June | 52 | 56 | 108 |
| 2024 May | 64 | 66 | 130 |
| 2024 April | 53 | 49 | 102 |
| 2024 March | 53 | 59 | 112 |
| 2024 February | 52 | 47 | 99 |
| 2024 January | 50 | 66 | 116 |
| 2023 December | 52 | 38 | 90 |
| 2023 November | 41 | 36 | 77 |
| 2023 October | 30 | 34 | 64 |
| 2023 September | 39 | 31 | 70 |
| 2023 August | 50 | 26 | 76 |
| 2023 July | 57 | 35 | 92 |
| 2023 June | 64 | 29 | 93 |
| 2023 May | 69 | 32 | 101 |
| 2023 April | 47 | 27 | 74 |
| 2023 March | 51 | 72 | 123 |
| 2023 February | 54 | 42 | 96 |
| 2023 January | 53 | 30 | 83 |
| 2022 December | 78 | 50 | 128 |
| 2022 November | 68 | 62 | 130 |
| 2022 October | 55 | 76 | 131 |
| 2022 September | 34 | 71 | 105 |
| 2022 August | 52 | 85 | 137 |
| 2022 July | 46 | 64 | 110 |
| 2022 June | 63 | 61 | 124 |
| 2022 May | 48 | 72 | 120 |
| 2022 April | 59 | 63 | 122 |
| 2022 March | 52 | 99 | 151 |
| 2022 February | 39 | 80 | 119 |
| 2022 January | 52 | 101 | 153 |
| 2021 December | 55 | 70 | 125 |
| 2021 November | 51 | 105 | 156 |
| 2021 October | 64 | 92 | 156 |
| 2021 September | 40 | 87 | 127 |
| 2021 August | 30 | 55 | 85 |
| 2021 July | 48 | 57 | 105 |
| 2021 June | 48 | 62 | 110 |
| 2021 May | 44 | 62 | 106 |
| 2021 April | 123 | 104 | 227 |
| 2021 March | 99 | 75 | 174 |
| 2021 February | 86 | 50 | 136 |
| 2021 January | 62 | 62 | 124 |
| 2020 December | 71 | 72 | 143 |
| 2020 November | 36 | 43 | 79 |
| 2020 October | 39 | 24 | 63 |
| 2020 September | 39 | 17 | 56 |
| 2020 August | 33 | 39 | 72 |
| 2020 July | 90 | 45 | 135 |
| 2020 June | 17 | 53 | 70 |
| 2020 May | 25 | 49 | 74 |
| 2020 April | 22 | 41 | 63 |
| 2020 March | 21 | 34 | 55 |
| 2020 February | 23 | 16 | 39 |
| 2020 January | 46 | 29 | 75 |
| 2019 December | 46 | 47 | 93 |
| 2019 November | 28 | 30 | 58 |
| 2019 October | 18 | 27 | 45 |
| 2019 September | 21 | 23 | 44 |
| 2019 August | 26 | 25 | 51 |
| 2019 July | 29 | 24 | 53 |
| 2019 June | 17 | 48 | 65 |
| 2019 May | 33 | 58 | 91 |
| 2019 April | 24 | 52 | 76 |
| 2019 March | 13 | 13 | 26 |
| 2019 February | 21 | 21 | 42 |
| 2019 January | 11 | 16 | 27 |
| 2018 December | 33 | 22 | 55 |
| 2018 November | 36 | 19 | 55 |
| 2018 October | 43 | 18 | 61 |
| 2018 September | 28 | 11 | 39 |
| 2018 August | 2 | 0 | 2 |
| 2018 July | 8 | 0 | 8 |
| 2018 June | 2 | 0 | 2 |
| 2018 May | 6 | 0 | 6 |
| 2018 April | 13 | 0 | 13 |
| 2018 March | 11 | 0 | 11 |
| 2018 February | 13 | 0 | 13 |
| 2018 January | 10 | 0 | 10 |
| 2017 December | 15 | 0 | 15 |
| 2017 November | 13 | 0 | 13 |
| 2017 October | 14 | 0 | 14 |
| 2017 September | 19 | 0 | 19 |
| 2017 August | 4 | 0 | 4 |
| 2017 July | 22 | 1 | 23 |
| 2017 June | 20 | 6 | 26 |
| 2017 May | 18 | 8 | 26 |
| 2017 April | 13 | 4 | 17 |
| 2017 March | 15 | 25 | 40 |
| 2017 February | 11 | 5 | 16 |
| 2017 January | 8 | 1 | 9 |
| 2016 December | 26 | 9 | 35 |
| 2016 November | 40 | 7 | 47 |
| 2016 October | 64 | 10 | 74 |
| 2016 September | 35 | 5 | 40 |
| 2016 August | 42 | 8 | 50 |
| 2016 July | 18 | 7 | 25 |
| 2016 June | 3 | 0 | 3 |
| 2016 May | 3 | 0 | 3 |
| 2016 April | 4 | 0 | 4 |
| 2016 March | 6 | 0 | 6 |
| 2016 February | 3 | 0 | 3 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 12 | 0 | 12 |
| 2015 November | 2 | 0 | 2 |
| 2015 October | 5 | 11 | 16 |
| 2015 September | 12 | 11 | 23 |
| 2015 August | 10 | 11 | 21 |
| 2015 July | 20 | 0 | 20 |
| 2015 June | 8 | 0 | 8 |
| 2015 May | 23 | 0 | 23 |
| 2015 April | 28 | 0 | 28 |
| 2015 March | 15 | 0 | 15 |
| 2015 February | 12 | 0 | 12 |
| 2015 January | 16 | 0 | 16 |
| 2014 December | 19 | 1 | 20 |
| 2014 November | 17 | 0 | 17 |
| 2014 October | 14 | 0 | 14 |
| 2014 September | 23 | 4 | 27 |
| 2014 August | 33 | 2 | 35 |
| 2014 July | 28 | 1 | 29 |
| 2014 June | 44 | 2 | 46 |
| 2014 May | 50 | 2 | 52 |
| 2014 April | 32 | 5 | 37 |
| 2014 March | 41 | 10 | 51 |
| 2014 February | 33 | 12 | 45 |
| 2014 January | 41 | 8 | 49 |
| 2013 December | 39 | 14 | 53 |
| 2013 November | 39 | 24 | 63 |
| 2013 October | 48 | 9 | 57 |
| 2013 September | 22 | 30 | 52 |
| 2013 August | 38 | 18 | 56 |
| 2013 July | 33 | 7 | 40 |
| 2013 June | 5 | 3 | 8 |
| 2013 May | 2 | 3 | 5 |
| 2013 April | 2 | 3 | 5 |
| 2013 March | 5 | 4 | 9 |
| 2013 February | 18 | 1 | 19 |
| 2013 January | 10 | 3 | 13 |
| 2012 December | 6 | 1 | 7 |
| 2012 November | 6 | 1 | 7 |
| 2012 October | 3 | 2 | 5 |
| 2012 September | 2 | 0 | 2 |
| 2002 September | 2722 | 0 | 2722 |
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