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Images in Paediatrics
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Available online 29 September 2025
Infantile orbital hemangioma: A case report
Hemangioma infantil orbitario: a propósito de un caso
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Rachid Bouchikh-El Jarroudia,
, Hugo González-Valdiviab, Mariana Planells-Alduvínc, Mariana Alvarez-Vukovd
a Servicio de Oftalmología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
b Servicio de Oftalmología, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
c Servicio de Radiología, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
d Servicio de Anatomía Patológica, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
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An infant aged 4 months was referred for assessment of a purplish mass in the posterior surface of the right upper eyelid (Fig. 1), with no other abnormalities in the ophthalmological examination. Magnetic resonance imaging revealed a well-defined intramuscular mass in the superior rectus muscle of the right eye with characteristics suggestive—but not pathognomonic—of hemangioma (Fig. 2). The patient underwent an incisional biopsy at age 9 months. The histological analysis revealed proliferation of small-caliber vessels without atypia. Immunohistochemical staining was positive for GLUT-1, CD34 and WT-1, confirming the diagnosis of infantile hemangioma (Fig. 3). The patient started treatment with oral propranolol (Hemangiol), which was well tolerated and achieved a favorable response.1 Follow-up MRI scans showed progressive involution and fibrotic changes.

Figure 1.

Presentation. Intraoperative image showing the gross appearance of the lesion before performance of biopsy, with visualization of a purplish mass in the posterior surface of the right upper eyelid, resembling a morula, with a vascular appearance.

Figure 2.

Magnetic resonance imaging. (A) Coronal view and (B) sagittal view showing a homogeneous lesion, hyperintense on T2-weighted imaging, in the distal portion of the superior rectus muscle of the right eye, near the insertion on the globe, measuring 16 × 14 × 16 mm (anteroposterior × transverse × craniocaudal diameters), with a hypointense border corresponding to a pseudocapsule, showing facilitated diffusion, without calcification or bleeding within the lesion. (C) Dynamic contrast-enhanced MRI, fat-suppressed T1-weighted images showing a type 3 kinetic curve with a rapid uptake followed by a progressive reduction on the late phase (washout). Post-contrast imaging of the right superior rectus muscle showing homogeneous enhancement.

Figure 3.

Histological analysis of the specimen. (A) Hematoxylin-eosin stain showing proliferation of small vascular structures with a nodular arrangement over a thin collagenized stroma; immunohistochemistry positive for (B) GLUT-1, (C) WT-1 and (D) CD34.

Infantile hemangioma is the most frequent benign vascular tumor of infancy; it is absent at birth to then present in the first weeks of life, with a natural history in three phases: proliferation, stabilization and involution.2 The differential diagnosis includes rapidly involuting congenital hemangioma, present from birth and with rapid spontaneous involution, and non-involuting congenital hemangioma, which persists over time and is negative for GLUT-1 expression.3

The salient features of this case were the atypical location combined with the typical clinical course of orbital infantile hemangioma.

References
[1]
D.F. Sebaratnam, A.L. Rodríguez Bandera, L.C.F. Wong, O. Wargon.
Infantile hemangioma. Part 2: management.
J Am Acad Dermatol, 85 (2021), pp. 1395-1404
[2]
A.I. Rodríguez Bandera, D.F. Sebaratnam, O. Wargon, L.C.F. Wong.
Infantile hemangioma. Part 1: epidemiology, pathogenesis, clinical presentation and assessment.
J Am Acad Dermatol, 85 (2021), pp. 1379-1392
[3]
J.B. Mulliken, O. Enjolras.
Congenital hemangiomas and infantile hemangioma: missing links.
J Am Acad Dermatol, 50 (2004), pp. 875-882
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