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Vol. 60. Núm. 2.
Páginas 142-147 (Febrero 2004)
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Vol. 60. Núm. 2.
Páginas 142-147 (Febrero 2004)
Acceso a texto completo
Alteraciones relacionadas con el síndrome X y bajos niveles de vitamina E en niños con obesidad y acantosis nigricans
Metabolic alterations related to syndrome x and low vitamin e levels in obese children with acanthosis nigricans
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...
B. Bonet Serraa,b,
Autor para correspondencia
bbjbonet@fhalcorcon.es

Correspondencia: Servicio de Pediatría. Fundación Hospital Alcorcón. Budapest, 1. Alcorcón. 28922 Madrid. España
, I. Sánchez-Verab, P. Cocho Gómezc, A. Quintanar Riojaa, M. Bueno Campañaa, M. Espino Hernándeza
a Área de Pediatría y Neonatología. Fundación Hospital Alcorcón
b Universidad San Pablo-CEU
c Centro de Salud Parque Coimbra. Madrid. España
Información del artículo
Resumen
Bibliografía
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Estadísticas
Antecedentes

En adultos, tanto las alteraciones metabólicas asociadas al síndrome X, como la disminución en las concentraciones plasmáticas de vitamina E, se han asociado a un mayor riesgo de desarrollar enfermedades cardiovasculares

Objetivos

Estudiar en niños obesos con acantosis nigricans la presencia de alteraciones metabólicas relacionadas con el síndrome X y determinar las concentraciones plasmáticas de vitamina E

Métodos

Se llevó a cabo un estudio prospectivo en 42 niños obesos, 15 con acantosis nigricans (OB + AN) y 27 sin ella (OB − AN), y 13 niños sanos sin obesidad. En todos ellos, y tras 12 h de ayuno, se determinaron las concentraciones plasmáticas de glucosa, insulina, vitamina E, triglicéridos, colesterol y colesterol HDL. Se calculó el índice de resistencia a la insulina. Las diferencias entre grupos se determinaron mediante el análisis de la varianza

Resultados

Los niños obesos con acantosis nigricans presentaron mayores concentraciones de insulina plasmática y de triglicéridos, menores niveles de colesterol HDL (lipoproteínas de alta densidad) y de vitamina E en plasma, así como un índice de resistencia a la insulina más elevado que los niños obesos sin acantosis nigricans o que los valores observados en un grupo de niños sin obesidad

Conclusiones

La presencia de acantosis nigricans en niños obesos define a un grupo de niños con alteraciones metabólicas asociadas a un mayor riesgo de desarrollar enfermedades cardiovasculares y diabetes de tipo 2

Palabras clave:
Acantosis nigricans
Obesidad
Hiperinsulinismo
Vitamina E
Síndrome X
Background

In adults, both metabolic alterations related to syndrome X and lower plasma vitamin E levels have been associated with an increased risk of developing cardiovascular disease

Objectives

To study the presence of metabolic alterations related to syndrome X and to determine the plasma levels of vitamin E in obese children with acanthosis nigricans

Methods

We performed a prospective study in 42 obese children [15 with acanthosis nigricans (AN) and 27 without]. Thirteen healthy non-obese children were also studied. After a 12-hour fast, plasma levels of glucose, insulin, triglycerides, cholesterol, high-density lipoprotein (HDL)-cholesterol, and vitamin E were determined. The insulin resistance index was also calculated. Differences between groups were determined using ANOVA

Results

Obese children with AN showed higher plasma levels of insulin and triglycerides and lower plasma levels of HDL-cholesterol and vitamin E, as well as a higher insulin resistance index than non-obese children and obese children without AN

Conclusions

In obese children, the presence of acanthosis nigricans is linked to a group of metabolic alterations associated with a higher risk of developing cardiovascular disease and type 2 diabetes

Key words:
Acanthosis nigricans
Obesity
Hyperinsulinism
Vitamin E
Syndrome X
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